The ACA-positive group showed a significantly higher prevalence of Raynaud’s phenomenon (16.98%) and left ventricular diastolic dysfunction (50.94%) than the SSA-positive group (3.03% and 33.33%, respectively; P < 0.01 for Raynaud’s phenomenon and P < 0.05 for left ventricular diastolic dysfunction). The gene discussed is TRIM21; the disease is Left ventricular diastolic dysfunction.