CD8+ T cells also play a important role in the pathology of Sjögren’s syndrome, exerting cytotoxic effects that target glandular cells and result in glandular damage and dysfunction [32].Previous studies have shown increased T cell infiltration in the salivary glands of patients with Sjögren’s syndrome, primarily consisting of CD4+ and CD8+ T cells [33,34], with the latter rarely undergoing local proliferation during disease progression but being readily recruited and differentiated from peripheral sources [35]. This evidence concerns the gene CD4 and Sjogren syndrome.