In turn, they phosphorylate a set of substrates and control many biological processes, including circadian cycle (PER [period] 2 phosphorylation), cell-cell interaction and cancer (connexin-43 phosphorylation), Cap-dependent translation, regulation of AMPK (AMP-activated protein kinase) pathway and cancer (4EBP1 phosphorylation), and dopamine signaling and drug addiction (dopamine and cAMP-regulated phosphoprotein)−32 phosphorylation (39). Here, GJA1 is linked to cancer.