Mutations in AKT1, KLF4, POLR2A or SMO were mostly detected in meningothelial or transitional meningioma, except for three cases: one case of angiomatous meningioma with KLF4 mutation, one case of secretory meningioma with KLF4 mutation and one case of psammomatous meningioma with AKT1 mutation. The gene discussed is AKT1; the disease is Secretory Meningioma.