Another study of 88 cases of sporadic meningiomas found that 49% of cases had 22q loss, 24% had somatic NF2 mutations and 26% had aberrant NF2 promoter methylation, and that epigenetic NF2 inactivation was the sole cause of NF2 deficiency in 17% of meningiomas.40 Here, NF2 is linked to meningioma.