Unlike other alpha-synuclein overexpression mouse models (Giasson et al., 2002; Grant et al., 2014), the A53T SynGFP model does not develop spontaneous alpha-synuclein pathology over time and does not develop PD specific motor deficits with advanced age (Schaser et al., 2020). The gene discussed is SNCA; the disease is Parkinson disease.