Consistently it was demonstrated that the overexpressed glycoprotein mucin in cancer cells, with longer glycosylation chains, reduces the integrin binding rate of cancer cells and enhances integrin clustering and focal adhesion formation during adhesion maturation in a kinetic trap‐like manner.[32, 33] We thus propose that the thick and dense glycocalyx hinders integrin binding on HeLa cells to collagen I at low and medium compression, and that the partial removal of the glycocalyx increases integrin binding to collagen I due to the reduced physical barrier formed by glycocalyx. This evidence concerns the gene MUC5AC and cancer.