Having provided evidence in dysferlin‐null animals that high CHOL/HDL‐C ratios drastically exacerbate muscle wasting, an effect prevented with cholesterol absorption inhibitor ezetimibe [16, 33], it is tempting to speculate that the HDL‐C lipoprotein abnormalities we report in patients with LGMDR2 may be implicated in the process of skeletal muscle degeneration [33]. This evidence concerns the gene DYSF and Skeletal muscle atrophy.