Finally, analysis of CHOL/HDL‐C ratios, an indicator of cardiovascular disease risk, demonstrated that LGMD2R males had a higher prevalence of suboptimal (> 3.5 mmol/L) and abnormal (> 4.5 mmol/L) [32] and earlier commencement of CHOL/HDL‐C anomalies compared to female patients (89% vs. 48%; 4.95 + 0.18 mmol/L vs. 3.67 + 0.14 mmol/L, respectively, Figure 1D), which was again confirmed in LGMD2R COS study serum samples relative to control patients [17]. This evidence concerns the gene DES and cardiovascular disorder.