GLP1R and chronic kidney disease: Because SGLT2i and GLP1-RAs also affect sodium reabsorption in the renal proximal tubules and offer substantial nephroprotection to patients with CKD, it is tempting to speculate that some of the renal protection provided by SGLT2i and GLP1-RAs is due to the reduced sodium reabsorption at the renal proximal tubule level.