MAPKBP1 and kidney disorder: Since its discovery as NPH-associated gene in 2016,4 16 patients from 12 families with biallelic loss-of-function variants in MAPKBP1 have been reported (Figure 1a and b; Supplementary Table S3).4, 5, 6, 7, 8, 9 Together with another unpublished case in a cohort of 121 Saudi Arabian kidney disease patients (Supplementary Figure S1), we included 14 different genetic variations comprising 9 homozygous and 3 compound heterozygous combinations (Supplementary Table S3).