Results did not materially change when we additionally adjusted for NT-proBNP (HR: 1.25; 95% CI: 1.04–1.50), interim HF (HR: 1.28; 95% CI: 1.07–1.53) or competing risk of death (HR: 1.26; 95% CI: 1.05–1.53). This evidence concerns the gene NPPB and hydrops fetalis.