In Cox proportional hazards models, IGFBP7 was associated with increased risk for incident AF (unadjusted hazard ratio [HR]: 1.85 per 1-SD increase in log-IGFBP7; 95% confidence interval [CI]: 1.65–2.07) which remained significant after adjustment for clinical variables (HR: 1.28; 95% CI: 1.07–1.52). Here, IGFBP7 is linked to atrial fibrillation.