Furthermore, one recent study found that O-linked N-acetylglucosamine transferase, a glycosylation enzyme increased in many tumors and promoted tumor growth, reduce its polyubiquitination and degradation by phosphorylation of ACSS2 in a cyclin-dependent kinase 5 (CDK5)-dependent manner, resulting in subsequent stimulation of acetate-driven DNL.73 Here, ACSS2 is linked to neoplasm.