Our study, which used a large, well-characterised prospective birth cohort with strategies implemented to address missing data, confirmed previous research which demonstrated that childhood trauma and PRSs for different psychiatric disorders confer risk of a range of psychopathologies in adulthood.15,28 However, although immune dysfunction has been implicated as a possible biological pathway in psychopathology, we found little evidence that raised IL-6 or CRP levels in childhood mediated these associations. This evidence concerns the gene CRP and immune system disorder.