However, evidence from the population-based Avon Longitudinal Study of Parents and Children (ALSPAC) showed that higher IL-6 levels in childhood were associated with subclinical schizophrenia symptoms associated with psychotic disorders, namely psychotic experiences and negative symptoms, as well as depression in early adulthood, arguing against the latter and providing evidence of a possible causal pathway.14 The gene discussed is IL6; the disease is major depressive disorder.