When in co‐culture with Schwann cells, myelination of nociceptor was observedMyelin was damaged in hyperglycemia conditions but mitigated by epalrestat administrationRTX exposure led to a release of substance P from nociceptorsRTX induces neurite retraction, but when administered with CPZ, neurite remained unaffectedAgonist and antagonist assays were performed without the pancreatic pseudoislets and human endometrium spheroids. This evidence concerns the gene TAC1 and Hyperglycemia.