CPZ and Hyperglycemia: When in co‐culture with Schwann cells, myelination of nociceptor was observedMyelin was damaged in hyperglycemia conditions but mitigated by epalrestat administrationRTX exposure led to a release of substance P from nociceptorsRTX induces neurite retraction, but when administered with CPZ, neurite remained unaffectedAgonist and antagonist assays were performed without the pancreatic pseudoislets and human endometrium spheroids