The SMR analysis employing rigorous IV selection identified FAHD1 as the sole DEPRGs, where genetic variants demonstrate a significant association with HCC susceptibility suggestive of a potential causal role (P_SMR = 0.02, P_HEIDI = 0.83, β = 0.129; Figures 5A and 5B; Table S3). The gene discussed is FAHD1; the disease is hepatocellular carcinoma.