In intervertebral disc degeneration (IVDD) models, KMT2A-mediated H3K4me3 upregulated methyltransferase-like 3 (METTL3), leading to reduced ATG4a mRNA stability via m6A modification, thereby suppressing autophagy in nucleus pulposus cells (NPCs) and accelerating SASP expression [152, 153]. Here, METTL3 is linked to Intervertebral disk degeneration.