SIRT1 and chronic obstructive pulmonary disease: Furthermore, class III HDACs (e.g., SIRT1/SIRT6) regulated histone acetylation to counteract lymphocyte senescence in COPD and conferred vascular protection [189, 231].A clinical study demonstrated that time-restricted feeding (TRF) enhanced the expression of the deacetylase SIRT1 and promoted autophagy, thereby exerting anti-aging effects in humans [232].