PNPLA3 and metabolic dysfunction-associated steatotic liver disease: One possible contributor to the higher prevalence of MASLD among Latinos is that a PNPLA3 single nucleotide polymorphism variant (I148M), a lipid regulator associated with hepatic steatosis, steatohepatitis, fibrosis, and cirrhosis [3], is more common among Latinos, with peoples of Mexican and Central American origin having the highest frequency (59–77%) [4].