At the same time, we identified novel CAR-T targets in GBM such as MRC2, ADAM12, ADAM17, TSPAN31, SDC3, or NOTCH1. Regarding bispecific CAR-T targets, we found 372 “AND” and 3028 “AND-NOT” target pairs in GBM (Additional file 1:Table S36, TableS37). The gene discussed is ADAM17; the disease is glioblastoma.