For example, the abnormal GBM expression of LAIR1, whose expression is normally restricted to immune cells, allows its co-targeting with genes of glial or neuronal lineage also expressed in GBM cells, such as ASTN2, GPM6A, EPHB1, NRXN1, or NCAM1. In contrast, pairing genes that are expressed in normal neuronal or glial cells but not in GBM cells, as GABRA1, GABRA3, HCN2, CACNA1G, or GRM4, with tumor-associated genes like BCAN, TENM4, GPM6A, PCDH9, or GPR37L1 allowed us to define putative “AND-NOT” CAR-T target pairs in GBM (Fig. 7E). This evidence concerns the gene HCN2 and glioblastoma.