For example, in UPS, tumor-associated genes which are also expressed in the nervous system like GPC6, ROR1, or THY1, could be safely targeted by and AND-NOT CAR whose inhibitory domain recognizes a gene normally expressed in neuronal cells but not found in UPS cells, as GABA receptors, GABRA4 and GABRA5, or potassium channels, KCNA6 and KCNC2 (Additional file 2:Fig S5E). This evidence concerns the gene GABRA4 and neoplasm.