We show targetable pathways and protein families in STS, including semaphorins and plexins that are physiologically involved in neural development [217] and poorly studied in STS [218]; the NOTCH pathway, previously targeted in STS [219, 220]; the EPH/Ephrin system, described as pathogenic in sarcomas [221] and physiologically involved in neuron migration, axon guidance, and vascular remodeling [222]; and the WNT/β-Catenin pathway, implicated in sarcomagenesis and previously targeted in STS [223]. This evidence concerns the gene EPHA1 and sarcoma.