The most recent studies associate TRPML1 with Zn2+ lysosomal necrotic cell death in metastatic melanoma, TRPA1 with ROS accumulation and consequent mitochondrial dysfunction in glioblastoma, breast and colorectal cancer, and finally modulation of TRPM2 and TRPV1 activity in colitis-associated cancer with protection of colon tissue from oxidative damage. This evidence concerns the gene TRPM2 and colorectal cancer.