Recent studies have elucidated the crucial role of TRP channels, specifically TRPC3 [43],TRPC5 [44, 45],TRPV4 [46] TRPML3 [47], in regulating the release, cargo content, and downstream effects of cancer-derived exosomes within the tumor microenvironment (TME). The gene discussed is TRPC5; the disease is neoplasm.