The most recent studies associate TRPML1 with Zn2+ lysosomal necrotic cell death in metastatic melanoma, TRPA1 with ROS accumulation and consequent mitochondrial dysfunction in glioblastoma, breast and colorectal cancer, and finally modulation of TRPM2 and TRPV1 activity in colitis-associated cancer with protection of colon tissue from oxidative damage. The gene discussed is TRPV1; the disease is metastatic melanoma.