HIF1A and neoplasm: In hepatocellular carcinoma, hypoxia-induced TRPM7 expression stabilizes HIF-1α and activates the PI3K/AKT pathway, enhancing glycolytic flux and tumor progression, while its silencing in ovarian cancer leads to AMPK activation and subsequent HIF-1α degradation through the PHD-VHL axis, thereby disrupting hypoxia-driven metabolic plasticity [11, 12, 95].