NFKB1 and esophageal squamous cell carcinoma: To investigate the biological impact of enriched KIN in ESCC, we performed GSEA of DEGs between the KIN-high group and the KIN-low group in both the TCGA ESCA dataset and the HRA003107 dataset, which revealed enrichment of TNFA signaling via NFKB (Fig. 6a, b).