HAS1 and neoplasm: By measuring the maximum invasion distance of HN6, HSC3, and CAL27 tumor spheroids on dECM derived from CAFIF-NC and CAFIF-shHAS1, we observed that knockdown of HAS1 in CAFIF significantly impaired the pro-invasive capacity of CAFIF-derived ECM (p < 0.05) (Fig. 6b-c).