MYCN and neuroblastoma: Extending studies to PDX models, cells dissociated from 3 MYCN-amplified PDX tumor models (zccs373, COG-N-424X, COG-N-440X) were found to have similar sensitivities to BCT (IC50 values 145–200 ng/mL; Fig. 6A) as the four neuroblastoma cell lines from Fig. 4D (IC50 values 136–171 ng/mL).