NR5A1 and acromegaly: We assessed the association of each module with the expression of genes encoding for lineage-specific TFs (NR5A1, POU1F1, and TBX19), as well as with tumor subtypes: SF-1–positive gonadotrophs, TPIT-positive corticotrophs, general PIT-1 lineage tumors (including the POU1F1/NR5A1-expressing ones) and the three transcriptomic subtypes of acromegaly-associated tumors (Fig. 1E).