LHB and neoplasm: Furthermore, the results confirmed an abnormal increase in the expression of SF-1–induced genes in Subtype 1 somatotroph tumors (PIT-1/SF-1–positive), including steroidogenesis-related genes and GNRHR, but not LHB and FSHB. Finally, we observed a tumor-specific decrease in the expression of cell adhesion and cell cycle-related genes in Subtype 3 tumors.