Previous studies from our group have demonstrated that miR-7 targets key regulators of insulin homeostatic functions, including insulin receptor (INSR) or insulin-degrading enzyme (IDE), as well as key pathways in cholesterol metabolism such as liver X receptors (LXR), pointing this miRNA as a central modulator of cellular pathways linked to human metabolic disorders [13, 14]. Here, INSR is linked to metabolic disease.