We previously established a murine model of MDS using patient-derived CBL exon 8/9 deletion (CBLΔE8/9) and RUNX1 S291 frameshift mutation (RUNX1S291fs) via BM transplantation (BMT), which showed phenotypically relevant characteristics of MDS-ineffective hematopoiesis including thrombocytopenia [15]. Here, RUNX1 is linked to myelodysplastic syndrome.