Consistent with these observations and in addition to E2F targets, Myc targets (HALLMARK_MYC_TARGETS_V1 and HALLMARK_MYC_TARGETS_V2) were enriched in MDS patients with thrombocytopenia and in MDS–non-IB patients in our clinical data (Supplementary Table 1) and the GSE114922 dataset (Supplementary Table 5), respectively. The gene discussed is MYC; the disease is myelodysplastic syndrome.