Our main findings are that (1) patients with ischemic stroke have lower plasma concentrations of EVs from activated platelets (CD62p+) and leukocytes (CD45+) compared to all other patients, (2) within the group of ischemic stroke patients, patients with an LVO have lower concentrations of leukocyte EVs (CD45+) than patients with non-LVO ischemic strokes, and (3) patients with a subarachnoid hemorrhage have higher concentrations of platelet EVs (CD41+) compared to all other patients. The gene discussed is PTPRC; the disease is ischemic stroke.