For example, a patient with CD carried a germline VUS in AIP gene; although the variant was previously reported in a cohort of patients with somatotropinomas, functional studies have shown conflicting evidence regarding its effect on protein function, AIP pathogenic variants in corticotropinomas are rare, and the patient also carried a somatic USP8 pathogenic variant [20, 27, 28]. This evidence concerns the gene USP8 and growth hormone-producing pituitary gland neoplasm.