Pediatric pituitary adenomas (PAs) especially hormone-secreting, such as corticotroph PAs leading to adrenocorticotropin hormone (ACTH) excess causing Cushing’s disease (CD) or somatotroph PAs leading to growth hormone (GH) excess (GHE) causing gigantism/acromegaly, are rare pediatric endocrine conditions [1–3]. The gene discussed is GH1; the disease is acromegaly.