However, patients with USP8 pathogenic variants had larger tumors (median tumor size: 9.5 mm [6.5, 13.3] vs. 6.0 mm [4.0, 7.0] in patients without USP8, p= 0.048), and they had higher chance of having macroadenomas (50.0%) compared to those without USP8 variants (9.4%, p= 0.039) (Fig. 2). Here, USP8 is linked to neoplasm.