With no discernible changes in anxiety level and locomotor function (Fig. 8l and Supplementary Fig. 4m–o), immobility time was significantly reduced in FGFR1-activated mice with Numb knockdown, compared with both FGFR1-inactive mice with Numb knockdown and FGFR1-activated mice without Numb knockdown (Fig. 8m). Here, NUMB is linked to Anxiety.