Their research found that 44% of pediatric GBM tumors harbored somatic mutations in the H3.3 ATRX-DAXX chromatin remodeling pathway, with 31% of these tumors exhibiting recurrent H3-3A (previously named H3F3A) histone mutations resulting in H3.3 K27M or H3.3 G34R/V. Here, ATRX is linked to glioblastoma.