We then humanized this antibody via homology remodeling, and confirmed cross-species reactivity with murine surface ALK determined via flow cytometry with CDX0239 on spontaneously occurring murine neuroblastoma tumors (1331, 13387, 13389) derived from the murine Th-MYCN model40 (Supplemental Fig. 1). This evidence concerns the gene ALK and neuroblastoma.