Median ALK RNA expression outliers was highest in descending order of neuroblastoma (21.64, n = 201), fusion-positive rhabdomyosarcoma (17.69, n = 49), dysembryoplastic neuroepithelial tumor (8.13, n = 14), Ewing sarcoma (6.75, n = 85), ganglioglioma (2.62, n = 47), glioblastoma multiforme (2.47, n = 200), cutaneous melanoma (2.27, n = 469), diffuse midline glioma (2.25, n = 82), and high-grade glioma (0.72, n = 149) with minimal or absent ALK RNA expression in other neoplastic histologies (Supplemental Table 1). The gene discussed is ALK; the disease is diffuse midline glioma.