Novel variants found in this study that may potentially be associated with early-onset dementia include: p.L597W, p.V375I, p.L364F, p.A209T, p.D460N, p.R409C, and p.V227L variants in APP; p.R54X and p.M457V in PSEN1; p.H169R, p.D320N, and p.G349R in PSEN2; p.R556C and p.V28fs in GRN; p.G332LfsX64 and p.G701R in MAPT; p.G103D and p.A42T in GBA1; p.R556C in TARDBP, p.N42S and p.R507I in TBK1; p.E275G and p.D271N in APOE and TREM2 p.W44X. The gene discussed is APOE; the disease is dementia.