We screened genetic variants in key genes linked to these conditions, including APP, PSEN1, PSEN2, TREM2, MAPT, GRN, GBA1, SNCA, TBK1, TARDBP, and APOE across a total of 25,001 AD/ADRDs cases and 93,542 control individuals, collectively representing 11 ancestries. This evidence concerns the gene PSEN2 and Alzheimer disease.