Given that tumor-infiltrating CD4+ and CD8+ T cells may arise from naïve, central memory, or effector memory precursor cells (26), we analyzed CD4+ and CD8+ T cells from the spleen, TDLNs, and tumors of mice receiving the 3 types of therapy and compared the results with untreated controls (Fig. 6). The gene discussed is CD8A; the disease is neoplasm.