In addition, the disease is linked to type 1 diabetes (T1D) human leukocyte antigen (HLA)-risk alleles like DR4, which support an autoimmune origin of the disease.1 4 7 8 There has been a general lack of access to pancreatic tissue in patients affected by CPI-D, which has hindered our understanding of the pathogenesis of the disease. The gene discussed is TNFRSF10A; the disease is type 1 diabetes mellitus.