Mutations that constitutively activate (CA) G protein α-subunits encoded by GNAQ or GNA11 (CA-GNAQ/11) drive oncogenesis in >90% of uveal melanoma (UM) tumors (1, 2, 3, 4), occur in uncommon subsets of several other cancers, including ∼10% of cutaneous melanomas and 1% to 5% of other tumors, including glioblastoma multiforme as well as lung, colorectal, and pancreatic adenocarcinomas (5, 6), and cause Sturge–Weber syndrome (7). The gene discussed is GNA11; the disease is uveal melanoma.