Unexpected, we found transient expression of a plasmid for BRD4 T1186A/T1212A mutant, a mutant with a critical role in anisomycin and heat shock-induced BRD4 release from chromatin-targeting (28), had little effect against HSV-1 lytic infection (Fig. S1), suggesting other mechanisms may exist. The gene discussed is BRD4; the disease is infection.