CRP and insomnia: Other potential pathways may involve inflammation, with supporting evidence derived from studies documenting an association between insomnia and elevation in inflammatory cytokines such as CRP (C-reactive protein) and IL (interleukin)-6.106,107 However, because negative findings have also been reported,108,109 it remains unclear whether insomnia elicits a proinflammatory state that could play a role in AF development.