The ratio of CNBP/MBNL1 in the context of DM2 may also be less useful than DMPK/MBNL1 in DM1 since additional RBPs such as RBFOX1/2 have been reported as additionally sequestered by the CCUG repeats in DM2 (16). Here, MBNL1 is linked to myotonic dystrophy type 1.