Moreover, the cathelicidin LL37, overexpressed in psoriatic skin, binds self-DNA to induce type I interferons and IL-17 production, while promoting LDL uptake in macrophages via LDL receptor (LDLR), scavenger receptor B1 (SR-B1), and CD36, leading to cholesterol accumulation and atherosclerosis, and linking psoriatic inflammation to increased CV risk [35]. This evidence concerns the gene LDLR and atherosclerosis.