In another research, researchers found that the impairment of endothelial SIRT6 expression links diabetes to HFpEF through the alteration of FA transport across the endothelial barrier.[11] These studies on SIRT6 and myrisic acid precursor suggest that SIRT6's role in CVDs may involve complex lipid metabolism interactions—a key direction for future clinical data collection. Here, SIRT6 is linked to diabetes mellitus.