Our study advances the understanding of sleep disorders in periodontal pathogenesis through three novel discoveries: While prior research established epidemiological links between sleep disorders and periodontitis,[45, 46, 47, 48] we elucidated the mechanistic axis via in vivo/in vitro models demonstrating that SD activates trigeminal ganglion‐derived AChE transmission, disrupting the ACh/α7nAChR balance and suppressing CAP function. This evidence concerns the gene CHRNA7 and sleep disorder.