EDN1 and ulcer disease: The endothelin system has an important role in cardiovascular pathophysiology,[25] and endothelin receptor antagonism is an established therapeutic strategy for pulmonary arterial hypertension (PAH) and scleroderma‐related digital ulceration in clinical practice.[26] More importantly, ET‐1 has been proven to be involved in various pain processes and contributes to mechanical allodynia.[10, 12] Here, we hypothesized that ET‐1, which is secreted primarily from ECs and is a potent vasoactive peptide that plays a prominent role in peripheral pain,[10, 12] also plays an important role in VP.