SPECC1 and viral infectious disease: Necroptosis has long been considered as a ‘trap door’ alternative to extrinsic apoptosis during viral infections, as blocking the activity of caspase‐8 can promote necroptosis.[59, 60] Consequently, the inhibition of caspase‐8 activation by SARS2‐NSP5 and ‐ORF6 could potentially redirect the virus toward this pro‐necrotic pathway.