ADRB3 and type 2 diabetes mellitus: For example, beta-3-adrenergic receptor polymorphism is known to be associated with BMI and T2DM [51, 52], and in a cross-sectional study by Yoshihara et al. [12], the same polymorphism was associated with periodontal parameters, including clinical attachment loss and PD in postmenopausal women with a BMI ≥25 kg/m2.