We observed this relationship when assessing connectivity and tau covariance across the whole brain (Fig. 2C–H, PCA-AD: β = −0.53, P < 0.001, lvPPA-AD: β = −0.51, P < 0.001, bvAD: β = −0.37, P < 0.001, CBS-AD: β = −0.52, P < 0.001, typical AD: β = −0.43, P < 0.001, atypical AD altogether: β = −0.62, P < 0.001), as well as within seven individual functional brain networks (Fig. 2 A and B and Supplementary Fig. 3), suggesting that the association between connectivity and covariance in tau is not confined to specific high-tau regions. Here, MAPT is linked to Alzheimer disease.