In both PCA-AD and lvPPA-AD, we observed that greater covariance in tau-PET percentage change was associated with shorter functional connectivity-based distance, both across the whole brain (Fig. 5C and D; PCA-AD: β = −0.43, P < 0.001, lvPPA-AD: β = −0.28, P < 0.001) and in seven individual resting-state fMRI networks (Fig. 5A and B and Supplementary Fig. 8). The gene discussed is MAPT; the disease is Alzheimer disease.