Moreover, in lvPPA-AD it was primarily observed in right temporoparietal and occipital regions (Fig. 6B), which likely reflects the close functional connectivity of these regions to the baseline tau-PET epicentres of both variants.14,51,78 Moreover, for both PCA-AD and lvPPA-AD, a shorter functional connectivity-based distance to the tau accumulation epicentre was associated with faster tau-PET change, both when tested at the subject level (Fig. 6A and B) and per tracer at the group level (Supplementary Fig. 9). This evidence concerns the gene MAPT and Alzheimer disease.