MAPT and Alzheimer disease: An unexpected finding was the predominance of tau pathology in the posterior and temporal cortices in the CBS-AD group, contrasting with previous studies that showed significant involvement of the sensorimotor cortex.40,42 However, compared with the other AD variants, CBS-AD exhibited greater tau burden in the sensorimotor cortex, suggesting that it was relatively more affected in CBS-AD despite prominent tau accumulation in classical AD regions.