In particular, the primary visual cortex and visual association areas show prominent tau burden in PCA; the left superior temporal gyrus in lvPPA; temporoparietal and to a lesser extent frontal regions in bvAD; and predominantly the hemisphere contralateral to the clinically affected body side, including the sensorimotor cortex, in CBS.5,16,20,39-44 It is, therefore, of both scientific and clinical interest to better understand the mechanisms that drive heterogeneous tau progression patterns and subsequent clinical variability in AD. Here, MAPT is linked to Alzheimer disease.