MAPT and Alzheimer disease: Future research is warranted in several key areas, including: (i) advancing and validating functional connectivity-based models to more accurately predict individual levels of tau progression, ideally utilizing subject-level fMRI, because such mechanistic understanding will be crucial for identifying potential novel drug targets aimed at slowing or preventing tau accumulation; (ii) elucidating the role of Aβ burden in shaping tau progression patterns across AD variants.