Here, using Clec4g-iCre/Maffl/fl (MafLSEC-KO) mice with a high penetrance of excision from late fetal life onwards in a LSEC-selective manner, we demonstrate that loss of liver sinusoidal endothelial Maf caused MASH-like perisinusoidal liver fibrosis. The gene discussed is MAF; the disease is Hepatic fibrosis.