Moreover, emerging research indicates that BD is closely linked to brain and peripheral inflammation and immune dysfunction, characterized by heightened concentrations of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) among individuals with BD (34).These inflammatory markers not only contribute to the pathogenesis of BD, but are also associated with the development of MAFLD. This evidence concerns the gene IL6 and Behcet disease.