We found that DM duration, obesity, FPG, TG, Scr, eGFR, BUN, serum albumin, urinary protein in 24h, FIB, use of ACEI/ARB, anemia, hypocalcemia, MetS, number of MetS components, glomerulosclerosis rate, IFTA scores were risk factors for T2DN progression. This evidence concerns the gene ALB and anemia.