After adjusting for age, race, marital status, education level, PIR, smoking history, alcohol consumption, age at menopause, BMI, diabetes, albumin, AST, ALT, TG, HDL-c, LDL-c, SUA, and eGFR, the RCS analysis demonstrated a U-shaped relationship between eGDR and all-cause mortality, with an inflection point identified at eGDR = 5.11mg/kg/min (P for nonlinear = 0.009). This evidence concerns the gene ALB and diabetes mellitus.