Multivariable logistic regression analysis incorporating serum FTH and P (both significant in univariate analyses), along with Ca (a previously established contributor to CAC progression) and established cardiovascular risk factors (sex, BMI, and diabetes), identified serum FTH (EXP(B): 1.025, 95%CI: 1.001, 1.050, p=0.045) and P (EXP(B): 5.045, 95%CI: 1.025, 24.837, p=0.047) as independent predictors of CAC progression (Table 5). The gene discussed is FTH1; the disease is diabetes mellitus.