A meta-analysis conducted by Benton and Young (2016), examined the association between the Taq1A polymorphism (rs1800497), located near the DRD2 gene (which encodes the dopamine D2 receptor), and obesity, with implications for the Reward Deficiency Syndrome (RDS) theory. The gene discussed is DRD2; the disease is obesity due to melanocortin 4 receptor deficiency.