For instance, tsRNA-3043a promotes apoptosis in ovarian granulosa cells by targeting FLT1, thereby exacerbating premature ovarian insufficiency [7], In contrast, tsRNA-04002 inhibits apoptosis in nucleus pulposus cells by suppressing PRKCA, thus delaying intervertebral disc degeneration [8]. Here, FLT1 is linked to Premature ovarian insufficiency.