Among them, GAD1 is most tightly linked to CESD10 (“Having good sleep quality”) in the depression community (edge = 0.095); CESD1 is most closely associated with GAD6 (“Becoming easily annoyed or irritable”) in the anxiety community (edge = 0.070); and GAD7 is most strongly connected to CESD8 (“Feeling lonely”) in the depression community (edge = 0.078). This evidence concerns the gene GAD1 and major depressive disorder.