GAD1 and major depressive disorder: Among them, GAD1 is most closely related to CESD10 (“Having good sleep quality”) in the depression community (edge = 0.068); CESD1 is most strongly associated with GAD6 (“Becoming easily annoyed or irritable”) in the anxiety community (edge = 0.055); and GAD3 is most tightly connected to CESD4 (“Feeling increasingly exhausted and useless with age”) in the depression community (edge = 0.041).